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CYP2D6 inhibitos : Th CYP2D6 isozym can b inhibitd by a vaity dugs, .g. nuolptics, sotonin uptak inhibitos, bta blocks, and antiahythmics. xampls stong CYP2D6 inhibitos includ bupopion, luoxtin, paoxtin and quinidin. Ths dugs may poduc substantial dcass in TCA mtabolism and makd incass in plasma concntations. Consid tmonitTCA plasma lvls, whnv a TCA is tb co-administd with anoth dug known tb an inhibitCYP2D6. Dos adjustmnt amitiptylin may b ncssay (s sction 4.2).

• th tatmnt noctunal nusis in childn agd 6 yas and abov whn oganic pathology, including spina biida and latd disods, hav bn xcludd and nspons has bn achivd tall oth non-dug and dug tatmnts, including antispasmodics and vasopssin-latd poducts. This mdicinal poduct should only b pscibd by a halthca possional with xptis in th managmnt psistnt nusis.

Amitiptylin is a usul mdication som womn with plvic pain, but it’s otn had womn tundstand why it has bn commndd. It dosn’t suit vyon, but i you a somon with pain on most days th month, it can add a bit mtth oth tatmnts w o. Aound 1 in vy 2 womn whty it ind it hlpul.

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